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Tumor angiogenesis is frequently found in soft-tissue sarcomas (STSs), leading to high levels of aberrant vasculatures, acute and chronic hypoxia, and increased interstitial pressures within the STS microenvironment. Treatment of STS with angiogenesis inhibitors may renormalize the tumor vasculature. This would in turn increase tumor tissue oxygenation and reduce the interstitial pressure, thus increasing the sensitivity of the cells to radiotherapy. RT = radiotherapy.
