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. 2014 May 30;155(8):2996–3004. doi: 10.1210/en.2013-1411

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Copyright © 2014 by the Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the Endocrine Society the exclusive right to publish the article and identify itself as the original publisher.

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Figure 4. — Neuroendocrine responses and freezing behavior after contextual conditioned fear in wild-type and PrRP-deficient mice. A–D, Plasma concentrations of oxytocin (A), ACTH (B), total time spent for freezing behavior during stimuli (C), and cumulative time spent for freezing behavior during time course of stimuli (D) after control or contextual conditioned fear in wild-type and PrRP-deficient mice. Neuroendocrine responses after contextual conditioned fear disappeared, whereas freezing behavior was augmented in PrRP-deficient mice. **, P < .01; *, P < .05 compared with control mice; ##, P < .01; #, P < .05 compared with corresponding groups of wild-type mice; n = 8–10.