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. 2014 Feb 11;99(6):E953–E961. doi: 10.1210/jc.2013-1569

Figure 2.

Figure 2.

Effects of kisspeptin-54 on LH pulsatility in women with HA. A and C, Mean number of LH pulses (A) and LH pulse secretory mass (C) are presented for study visits during an iv infusion of vehicle or kisspeptin-54 (0.01, 0.03, 0.1, 0.3, or 1.0 nmol/kg/h). Peak responses to kisspeptin-54 were observed at different doses in each patient. We therefore also examined the peak number of LH pulses and peak secretory mass during any dose of kisspeptin-54 in each patient and present a mean value in all five subjects: peak response at any dose. Mean ± SEM of the number of pulses and pulse secretory mass are presented over 480 minutes except for the 1.0 nmol/kg/h dose, which was extended to 600 minutes. *, P < .05; **, P < .01. B and D, Dose response of the number of LH pulses (B) and LH pulse secretory mass (D) in each individual subject during an iv infusion of vehicle or each dose kisspeptin-54.