Table 5.
Effects of Drug Interventions on Steroids in Plasma and Urinea
| Dutasteride (n = 16) |
Finasteride (n = 16) |
Tamsulosin (n = 14) |
P, ANOVA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before | After | Change | Before | After | Change | Before | After | Change | ||
| Circulating steroids and binding proteins | ||||||||||
| Testosterone, nM | 25 (2) | 30 (3) | +5 (2) | 21 (2) | 24 (2) | +3 (1) | 21 (2) | 23 (3) | +2 (1) | .22 |
| DHT, nM | 2.9 (0.4) | 1.8 (0.4) | −1.1 (0.2)b | 2.1 (0.3) | 1.0 (0.2) | −1.1 (0.2)b | 2.0 (0.3) | 1.7 (0.3) | −0.3 (0.2) | .02 |
| Cortisol, nM | 788 (59) | 692 (47) | −96 (40) | 769 (51) | 689 (43) | −80 (54) | 818 (54) | 757 (42) | −61 (55) | .88 |
| Estradiol, pM | 81.8 (7.9) | 126.7 (16.9) | +44.9 (15.8) | 69.3 (7.4) | 94.0 (8.9) | +24.8 (6.9) | 73.4 (9.4) | 80.8 (10.9) | +7.4 (7.5) | .07 |
| SHBG, nM | 28 (2) | 27 (3) | −1 (1) | 24 (2) | 25 (2) | +1 (1) | 31 (3) | 33 (4) | +2 (2) | .25 |
| CBG, nM | 988 (43) | 966 (42) | −22 (36) | 936 (32) | 905 (53) | −31 (50) | 959 (34) | 929 (42) | −31 (23) | .75d |
| Albumin, g/L | 42 (1) | 39 (1) | −3 (1) | 43 (1) | 40 (1) | −3 (1) | 41 (1) | 40 (1) | −1 (1) | .26 |
| Urinary steroids | ||||||||||
| Androsterone (α), μg/d | 1806 (175) | 121 (18) | −1684 (163)b | 2373 (434) | 397 (78) | −1975 (397)b | 2116 (347) | 2036 (336) | −79 (268) | <.001 |
| Etiocholanolone (β), μg/d | 817 (101) | 2461 (338) | +1643 (283)b | 805 (151) | 1710 (251) | +905 (198)b | 861 (130) | 1029 (176) | +168 (99) | <.001d |
| 5α-THF, μg/d | 1664 (252) | 32 (9) | −1633 (249)b | 1858 (356) | 51 (13) | −1807 (346)b | 1786 (300) | 1773 (308) | −13 (200) | <.001 |
| 5β-THF, μg/d | 1724 (128) | 1718 (130) | −6 (127) | 1670 (162) | 1683 (127) | +13 (159) | 1793 (136) | 1742 (165) | −52 (199) | .96 |
| β-THF/α-THF | 1.39 (0.20) | 96.20 (16.68) | +94.81 (16.75)b | 1.21 (0.18) | 55.69 (8.34) | +54.48 (8.32)b | 1.30 (0.18) | 1.37 (0.24) | +0.07 (0.12) | <.001d |
| F/α-THF | 0.10 (0.03) | 6.12 (0.92) | +6.01 (0.92)b | 0.10 (0.01) | 4.22 (0.58) | +4.11 (0.58)b | 0.12 (0.03) | 0.13 (0.03) | +0.01 (0.02) | <.001d |
| F/β-THF | 0.08 (0.01) | 0.08 (0.01) | 0.00 (0.01) | 0.09 (0.01) | 0.08 (0.01) | −0.01 (0.00) | 0.09 (0.01) | 0.09 (0.01) | 0.00 (0.01) | .67 |
| Etiocholanolone/androsterone | 0.45 (0.05) | 21.82 (2.43) | +21.37 (2.43)b,c | 0.36 (0.05) | 8.26 (3.89) | +7.89 (3.88)b | 0.43 (0.04) | 0.85 (0.39) | +0.43 (0.38) | <.001d |
Abbreviations: F, cortisol; THF, tetrahydrocortisol.
a
Data are mean (SEM). ANOVA was conducted on absolute change in each variable from baseline, with LSD post hoc testing if ANOVA was significant (P < .05).
b
P ≤ .01 vs tamsulosin.
c
P ≤ .01 vs finasteride.
d
Kruskal-Wallis test with pairwise comparisons.