Table 3.

Ophthalmological findings

Assay	Aging phenotype	Intervention	Strain, sex	Treatment effects in aged mice	Treatment effects in young mice	References
Slit lamp examination with investigator-based rating of lens densities	Increased mean cataract score	Oral rapamycin (4.7, 14 or 42 ppm) initiated at 9 months of age	Male and female UM-HET3 mice	Cataract score further increased by treatment	Not examined	[18]
Scheimpflug imaging with computer-assisted automated measurements of lens densities	Increased mean lens density	Oral rapamycin (14 ppm) for approx. 1 year starting at 4 months or 13 months of age	Male C57BL/6J Rj	No effect	Not examined	[13]
Virtual drum vision test	Reduced visual acuity	Oral rapamycin (14 ppm) for approx. 1 year starting at 4 months or 13 months of age	Male C57BL/6J Rj	No effect	Not examined	[13]