Blood cell counts |
Reduced red blood cell couns, increased white blood cell counts and platelets |
Aging cohorts: oral rapamycin (14 ppm) for approx. 1 year starting at 4 months, 13 months or 25 months; young animals: oral rapamycin (14 ppm) for 3 months starting at 12 weeks of age |
Male C57BL/6J Rj |
Rapamycin increased red blood cell counts; no effect on white blood cell counts and platelets |
Increase of red blood cell counts |
[13] |
Clinical chemistry |
Increased plasma sodium, calcium, chloride, total protein, albumin, alkaline phosphatase, and α-amylase; decreased triglycerides |
Oral rapamycin (14 ppm) for approx. 1 year starting at 4, 13 or 25 months |
Male C57BL/6J Rj |
No amelioration of these aging traits |
Not examined |
[13] |
Immunology (FACS) |
Increased CD25+CD4+ T cell population; decreased γδ T cell population; increased CD44hi T cell populations |
Aging cohorts: oral rapamycin (14 ppm) for approx. 1 year starting at 4, 13 or 25 months; young animals: oral rapamycin (14 ppm) for 3 months starting at 12 weeks of age |
Male C57BL/6J Rj |
Decreased CD25+ CD4+ T cell population; increased γδ T cell population; decreased CD44hi T cell populations |
Decreased CD25+CD4+ T cell population; no effect on γδ T cell and CD44hi T cell populations (but see [48] and [56]) |
[13] |
Decreased CD4+ T lymphocytes; decreased NK cells and NK/CD11b+ cells; increased IgDhi B cells and MHCIIhi B cells |
No measurable amelioration of aging traits |
Not examined |
Immunoglobulin measurements |
Increased plasma immunoglobulin concentrations |
Tended to decrease plasma immunoglobulins (in part) |
Not examined |