. 2014 Jul 12;71(22):4325–4346. doi: 10.1007/s00018-014-1677-1

Table 7.

Metabolism

Assay	Aging phenotype	Intervention	Strain, sex	Treatment effects in aged mice	Treatment effects in young mice	Reference
Indirect calorimetry	Reduced oxygen consumption; lower body temperature	Aging cohorts: oral rapamycin (14 ppm) for approx. 1 year starting at 4, 13 or 25 months; young animals: oral rapamycin (14 ppm) for 3 months starting at 12 weeks of age	Male C57BL/6J Rj	No measurable effect	Not examined	[13]
Indirect calorimetry	Reduced respiratory exchange ratio (RER)		Male C57BL/6J Rj	Increased RER	No measurable effect	[13]