Table 9.

Rapamycin and gene expression studies using microarrays in mice

Strain, sex	Intervention	Organ	Genes up-regulated	Genes down-regulated	Pathways involved	Reference
Male and female C57BL/6J	Oral rapamycin (encapsulated, 14 ppm) initiated at 4 months of age for 21 months	Liver	159 (males), 2,504 (females)	129 (males), 2,257 (females)	13	[77]
	Oral rapamycin (encapsulated, 14 ppm) initiated at 19 months of age for 6 months		32 (males), 675 (females)	68 (males), 752 (females)	3
Male C57BL/6	Oral rapamycin (encapsulated, 14 ppm) initiated at 2 months of age with duration of 6 months	Liver	783	628	105	[78]
	40 % dietary restriction initiated at 2 months of age with duration of 6 months		1,621	256	88
	40 % dietary restriction combined with oral rapamycin treatment (encapsulated, 14 ppm) initiated at 2 months of age with duration of 6 months		2,558	1,130	170