Fig. 3.

Conserved structural elements in the RNA virus polymerase. a Structure of the FMDV RdRp. The motifs A, B, C, D, E, F, and G are colour coded yellow, gold, orange, red, light green, aquamarine, and blue. Overall the polymerase structure adopts a shape that resembles a cupped right hand. Herein, motifs A–E lie on the palm, while motif F and G are part of the fingers. In the side-view of the enzyme the location of the template and NTP channels is indicated. b Conserved structural elements of the FMDV RdRp. Homomorphs A–G were mapped according to Ref. [15] and colour coded yellow, gold, orange, red, light green, aquamarine, and blue, respectively. Images A and B are based on PDB accession 2E9R