Table 2.
Early Post-CPB (6 hours post-CPB) Gene Expression in Patients with NCD compared with NORM – Selected Genes Grouped by Potential Pathophysiologic Function
| Accession ID | Gene Name | FC | LCI | UCI | p value |
|---|---|---|---|---|---|
| Inflammation | |||||
| CLEC1B | C-type lectin domain family 1, member B | 1.56 | 0.0013 | ||
| TLR4 | toll-like receptor 4 | 1.78 | 1.18 | 2.67 | 0.0070 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.61 | 0.43 | 0.87 | 0.0075 |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.63 | 0.51 | 0.78 | 0.0001 |
| Cell death | |||||
| EPAS1 | endothelial PAS domain protein 1 | 1.73 | 1.31 | 2.27 | 0.0002 |
| ZBTB16 | zinc finger and BTB domain containing 16 | 1.94 | 1.32 | 2.86 | 0.0010 |
| Neurologic dysfunction | |||||
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 1.51 | 1.12 | 2.04 | 0.0074 |
Gene expression listed as fold change (FC) in neurocognitive decline (NCD) patients compared with normal patients (NORM).
All values represented are significant (p < 0.05). LCI: Lower confidence interval; UCI: Upper confidence interval