Table 4.
Preoperative Gene Expression in Patients with NCD compared with NORM – Complete List
| Accession ID | Gene Name | FC | LCI | UCI | p value |
|---|---|---|---|---|---|
| Upregulated | |||||
| ADA | adenosine deaminase | 1.54 | 1.14 | 2.08 | 0.0059 |
| ANAPC2 | anaphase promoting complex subunit 2 | 1.53 | 1.12 | 2.08 | 0.0081 |
| APOBEC3C | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | 1.73 | 1.24 | 2.40 | 0.0015 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 1.63 | 1.19 | 2.22 | 0.0027 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 1.73 | 1.21 | 2.46 | 0.0031 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 1.59 | 1.24 | 2.04 | 0.0004 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 1.55 | 1.14 | 2.11 | 0.0060 |
| ARL4C | ADP-ribosylation factor-like 4C | 1.51 | 1.15 | 1.99 | 0.0040 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | 1.73 | 1.23 | 2.43 | 0.0022 |
| ASXL2 | additional sex combs like 2 (Drosophila) | 1.55 | 1.15 | 2.08 | 0.0049 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 1.72 | 1.21 | 2.44 | 0.0032 |
| BPTF | bromodomain PHD finger transcription factor | 1.68 | 1.16 | 2.43 | 0.0073 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | 1.65 | 1.19 | 2.29 | 0.0034 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 1.85 | 1.30 | 2.63 | 0.0009 |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 1.77 | 1.28 | 2.44 | 0.0008 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 | 1.57 | 1.20 | 2.05 | 0.0014 |
| CNPPD1 | cyclin Pas1/PHO80 domain containing 1 | 2.02 | 0.0033 | ||
| CTSB | cathepsin B | 2.44 | 1.43 | 4.16 | 0.0015 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 2.48 | 1.46 | 4.23 | 0.0011 |
| E2F2 | E2F transcription factor 2 | 1.66 | 1.23 | 2.25 | 0.0014 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 2.25 | 1.25 | 4.03 | 0.0075 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 1.57 | 1.13 | 2.18 | 0.0080 |
| EML3 | echinoderm microtubule associated protein like 3 | 1.51 | 1.21 | 1.87 | 0.0004 |
| EPB41 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 2.07 | 1.30 | 3.30 | 0.0026 |
| FAM104A | family with sequence similarity 104, member A | 2.20 | 1.43 | 3.38 | 0.0006 |
| FAM117A | family with sequence similarity 117, member A | 1.86 | 1.20 | 2.89 | 0.0068 |
| FAM134A | family with sequence similarity 134, member A | 1.62 | 1.14 | 2.30 | 0.0083 |
| FAM46C | family with sequence similarity 46, member C | 2.62 | 1.31 | 5.26 | 0.0074 |
| FAXDC2 | fatty acid hydroxylase domain containing 2 | 1.67 | 0.0044 | ||
| FBXO9 | F-box protein 9 | 3.05 | 1.77 | 5.26 | 0.0001 |
| FECH | ferrochelatase | 2.81 | 1.42 | 5.56 | 0.0036 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 2.65 | 1.75 | 4.03 | 0.0000 |
| FOXO3 | forkhead box O3 | 1.99 | 1.26 | 3.15 | 0.0038 |
| FTO | fat mass and obesity associated | 1.63 | 1.15 | 2.32 | 0.0069 |
| FUNDC2 | FUN14 domain containing 2 | 1.86 | 1.20 | 2.87 | 0.0059 |
| GDE1 (includes EG:393213) | glycerophosphodiester phosphodiesterase 1 | 2.06 | 1.29 | 3.28 | 0.0030 |
| GSPT1 | G1 to S phase transition 1 | 3.16 | 1.51 | 6.61 | 0.0041 |
| HBZ | hemoglobin, zeta | 1.72 | 1.16 | 2.56 | 0.0082 |
| HECA | headcase homolog (Drosophila) | 1.50 | 1.12 | 2.02 | 0.0079 |
| HECTD3 | HECT domain containing E3 ubiquitin protein ligase 3 | 1.89 | 1.46 | 2.45 | 0.0000 |
| HEMGN | hemogen | 2.04 | 1.23 | 3.38 | 0.0066 |
| IBA57 | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) | 1.69 | 0.0007 | ||
| IL2RG | interleukin 2 receptor, gamma | 1.96 | 1.23 | 3.14 | 0.0058 |
| IL32 | interleukin 32 | 2.06 | 1.29 | 3.30 | 0.0032 |
| ITM2A | integral membrane protein 2A | 2.05 | 1.30 | 3.23 | 0.0027 |
| JHDM1D | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) | 1.74 | 1.17 | 2.59 | 0.0067 |
| JUND | jun D proto-oncogene | 1.57 | 1.18 | 2.10 | 0.0024 |
| KIAA1143 | KIAA1143 | 1.78 | 1.22 | 2.59 | 0.0032 |
| KIAA1919 | KIAA1919 | 1.90 | 1.36 | 2.64 | 0.0003 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 1.54 | 1.16 | 2.06 | 0.0037 |
| KPNA6 | karyopherin alpha 6 (importin alpha 7) | 1.51 | 1.15 | 1.99 | 0.0041 |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase | 2.52 | 1.43 | 4.43 | 0.0030 |
| MINK1 | misshapen-like kinase 1 | 1.56 | 1.20 | 2.02 | 0.0013 |
| MKRN1 | makorin ring finger protein 1 | 2.26 | 1.30 | 3.93 | 0.0046 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 1.51 | 1.20 | 1.90 | 0.0006 |
| NDUFV3 | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 1.53 | 1.12 | 2.07 | 0.0076 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 1.83 | 1.20 | 2.79 | 0.0058 |
| NTAN1 | N-terminal asparagine amidase | 1.94 | 1.27 | 2.97 | 0.0029 |
| OLA1 | Obg-like ATPase 1 | 1.83 | 1.26 | 2.64 | 0.0018 |
| PAQR8 | progestin and adipoQ receptor family member VIII | 1.58 | 1.20 | 2.09 | 0.0015 |
| PCGF5 | polycomb group ring finger 5 | 1.77 | 1.17 | 2.67 | 0.0081 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 1.52 | 1.13 | 2.05 | 0.0066 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 2.23 | 1.28 | 3.88 | 0.0055 |
| PITHD1 | PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 | 2.33 | 0.0011 | ||
| PNISR | PNN-interacting serine/arginine-rich protein | 1.85 | 0.0030 | ||
| PRDX2 | peroxiredoxin 2 | 2.41 | 1.34 | 4.31 | 0.0039 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 1.98 | 1.25 | 3.13 | 0.0043 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 1.82 | 1.22 | 2.72 | 0.0043 |
| PTPN4 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) | 1.57 | 1.15 | 2.14 | 0.0054 |
| RAB2B | RAB2B, member RAS oncogene family | 2.95 | 1.72 | 5.08 | 0.0002 |
| RALGDS | ral guanine nucleotide dissociation stimulator | 1.50 | 1.13 | 2.00 | 0.0064 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 1.89 | 1.30 | 2.75 | 0.0011 |
| RGCC | regulator of cell cycle | 2.11 | 0.0021 | ||
| RNF10 | ring finger protein 10 | 2.41 | 1.24 | 3.43 | 0.0059 |
| RNF123 | ring finger protein 123 | 2.03 | 1.25 | 3.31 | 0.0052 |
| RUNDC3A | RUN domain containing 3A | 1.95 | 1.34 | 2.82 | 0.0006 |
| SCML4 | sex comb on midleg-like 4 (Drosophila) | 1.67 | 1.15 | 2.43 | 0.0082 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 1.86 | 1.20 | 2.89 | 0.0069 |
| SECISBP2 | SECIS binding protein 2 | 1.97 | 1.21 | 3.20 | 0.0070 |
| SEPT6 | septin 6 | 1.50 | 1.14 | 1.97 | 0.0040 |
| SESN3 | sestrin 3 | 2.25 | 1.32 | 3.84 | 0.0035 |
| SF3A2 | splicing factor 3a, subunit 2, 66kDa | 2.03 | 1.46 | 2.84 | 0.0001 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 2.50 | 1.37 | 4.55 | 0.0034 |
| SLC38A5 | solute carrier family 38, member 5 | 1.57 | 1.15 | 2.14 | 0.0055 |
| SLC41A1 | solute carrier family 41, member 1 | 1.51 | 1.32 | 1.73 | 0.0000 |
| SLC48A1 | solute carrier family 48 (heme transporter), member 1 | 1.63 | 1.32 | 2.03 | 0.0000 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 2.08 | 1.22 | 3.54 | 0.0080 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 1.59 | 1.22 | 2.08 | 0.0009 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 2.01 | 1.22 | 3.30 | 0.0068 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 2.05 | 1.30 | 3.24 | 0.0026 |
| SSBP3 | single stranded DNA binding protein 3 | 1.62 | 1.18 | 2.22 | 0.0036 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 1.74 | 1.24 | 2.45 | 0.0020 |
| STAT4 | signal transducer and activator of transcription 4 | 1.71 | 1.17 | 2.51 | 0.0062 |
| SUN2 | Sad1 and UNC84 domain containing 2 | 1.63 | 0.0024 | ||
| TMEM245 | transmembrane protein 245 | 1.93 | 0.0031 | ||
| TMEM86B | transmembrane protein 86B | 1.56 | 1.14 | 2.14 | 0.0068 |
| TMOD1 | tropomodulin 1 | 1.75 | 1.18 | 2.58 | 0.0059 |
| TNS1 | tensin 1 | 3.03 | 1.53 | 6.03 | 0.0033 |
| TOLLIP | toll interacting protein | 1.74 | 1.17 | 2.59 | 0.0070 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 2.02 | 0.0068 | ||
| TRIM58 | tripartite motif containing 58 | 2.49 | 1.35 | 4.60 | 0.0041 |
| TSPAN5 | tetraspanin 5 | 2.74 | 1.57 | 4.76 | 0.0006 |
| TUBB2A | tubulin, beta 2A class IIa | 4.58 | 1.64 | 12.80 | 0.0041 |
| WDR26 | WD repeat domain 26 | 2.44 | 1.46 | 4.10 | 0.0010 |
| WDR45 | WD repeat domain 45 | 1.89 | 1.22 | 2.87 | 0.0048 |
| WNK1 | WNK lysine deficient protein kinase 1 | 1.92 | 1.22 | 3.02 | 0.0056 |
| YY1 | YY1 transcription factor | 1.97 | 1.31 | 2.97 | 0.0015 |
| ZMAT2 | zinc finger, matrin-type 2 | 1.82 | 1.20 | 2.76 | 0.0058 |
Gene expression listed as fold change (FC) in neurocognitive decline (NCD) patients compared with normal patients (NORM).
All values represented are significant (p < 0.05). LCI: Lower confidence interval; UCI: Upper confidence interval