TABLE 3.
Liver nuclear uracil in DNA in Mthfd1gt/+ mice
DNA uracil of Mthfd1+/+ and Mthfd1gt/+ independent of diet are significantly different as analyzed by 2-way analysis of variance (n = 5 and the values are stated as the means ± S.E. of the mean). NS, no significant difference.
| Diet | Mthfd1 Genotype | Uracil DNA content |
|---|---|---|
| pg/μg of DNA | ||
| AIN-93G (control) | Mthfd1+/+ | 0.23 ± 0.01 |
| Mthfd1gt/+ | 0.17 ± 0.01 | |
| AIN-93G minus folate (FD) | Mthfd1+/+ | 0.21 ± 0.02 |
| Mthfd1gt/+ | 0.19 ± 0.02 | |
| p Value, diet effect | NS | |
| p Value, genotype effect | 0.013 | |
| p Value, diet x genotype effect | NS |