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LSD1 regulates lipogenic gene expression in HEK293 cells. A, immunoblots show LSD1 knockdown in HEK293 cells by lentivirus-based shRNA. B–E, effects of LSD1 knockdown on the mRNA levels of FAS (B) and SREBPs (D) as detected by qRT-PCR, and the activities of the wild-type or sterol response element-mutated FAS promoters (C) and the SREBP-1a or SREBP-1c promoters (E) as measured by luciferase reporter assays. The data represent means ± S.D. (n = 3). #, p < 0.01; &, p < 0.001 versus NS.
