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. 2014 Sep 8;289(43):30063–30074. doi: 10.1074/jbc.M114.593616

FIGURE 2.

FIGURE 2.

Co-localization of GCase-XX- or GCase-XXX-GFP with LysoTracker. Pearson indices were obtained (see “Methods”) for co-localization of the WT or truncated GCases using LysoTracker to label the lysosomes. The construct containing only GFP (N-GFP) showed no co-localization. Compared with the WT sequence, GCase-23 and -75 showed only small decreases in lysosomal localization. GCase-150 and -225 showed decreases in co-localization with LysoTracker to nearly background (N-GFP) levels. GCase-150 and -225 showed much more extensive retention in the ER and Golgi compared with WT, GCase-23, or GCase-75 (data not shown). Error bars, S.E.