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IL-6- and TNF-α-induced luciferase expression is dependent on the STAT/NFκB site. A, point mutations of the STAT/NFκB site were generated in FasP-luc. Luciferase assays were performed for the empty vector (tkluc), FasP-luc (wild-type), and the mutant constructs, G1086A, G1085A, G1084A, and AA1082CC in response to IL-6 (B), TNF-α (C), or both IL-6 and TNF-α combined (D). Results represent the averages and S.D. of three independent experiments.
