TABLE 2.

Peptides from E1p selected for HDX-MS analysis

Peptides			Monoisotopic mass [M + H]+		Error
Number	Position	Sequence	Experimental	Theoretical
			Da		ppm
1	1–12	SERFPNDVDPIE	1417.6596	1417.6594	0.2
2	1–15	SERFPNDVDPIETRD	1789.8354	1789.8351	0.2
3	1–17	SERFPNDVDPIETRDWL	1789.8352	1789.8351	0.1
4	1–19	SERFPNDVDPIETRDWLQA	2288.0966	2288.0942	1.0
5	18–23	QAIESV	2088.9974	2088.9985	−0.5
6	24–39	IREEGVERAQYLIDQL	646.3406	646.3406	0.0
7	40–58	LAEARKGGVNVAAGTGISN	1932.0200	1932.0185	0.8
8	60–77	INTIPVEEQPEYPGNLEL	2055.0264	2055.0281	−0.8
9	78–91	ERRIRSAIRWNAIM	1771.9863	1771.9861	0.1
10	92–110	TVLRASKKDLELGGHMASF	1784.9600	1784.9613	−0.7
11	111–118	QSSATIYD	884.3996	884.3996	0.0
12	125–135	FRARNEQDGGD	1264.5660	1264.5665	−0.4
13	136–148	LVYFQGHISPGVY	1479.7627	1479.7631	−0.3
14	149–165	ARAFLEGRLTQEQLDNF	2008.0263	2008.0247	0.8
15	166–186	RQEVHGNGLSSYPHPKLMPEF	2423.1920	2423.1925	−0.2
16	187–225	WQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVY	4471.3628	4471.3635	−0.2
17	226–243	AFLGDGEMDEPESKGAIT	2060.0966	2060.0957	0.4
18	244–255	IATREKLDNLVF	1418.7989	1418.8002	−0.9
19	256–261	VINCNL	1866.8409	1866.8426	−0.9
20	262–277	QRLDGPVTGNGKIINE	675.3487	675.3494	−1.0
21	278–282	LEGIF	578.3184	578.3184	0.0
22	283–301	EGAGWNVIKVMWGSRWDEL	1710.9120	1710.9133	−0.8
23	302–310	LRKDTSGKL	1017.6049	1017.6051	−0.3
24	311–316	IQLMNE	747.3699	747.3706	−0.9
25	317–347	TVDGDYQTFKSKDGAYVREHFFGKYPETAAL	2233.0843	2233.0859	−0.7
26	348–387	VADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVIL	4497.4071	4497.4041	0.7
27	388–404	AHTIKGYGMGDAAEGKN	1719.8113	1719.8119	−0.3
28	388–414	AHTIKGYGMGDAAEGKNIAHQVKKMNM	3540.7103	3540.7070	0.9
29	388–432	AHTIKGYGMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDAD	4949.4510	4949.4468	0.8
30	415–432	DGVRHIRDRFNVPVSDAD	2900.4326	2900.4328	−0.1
31	433–441	IEKLPYITF	1123.6387	1123.6398	−1.0
32	442–469	PEGSEEHTYLHAQRQKLHGYLPSRQPNF	3319.6384	3319.6355	0.9
33	470–475	TEKLEL	732.4133	732.4138	−0.7
34	476–484	PSLQDFGAL	2068.0309	2068.0319	−0.5
35	485–495	LEEQSKEISTT	947.4826	947.4833	−0.7
36	499–531	VRALNVMLKNKSIKDRLVPIIADEARTFGMEGL	1264.6261	1264.6267	−0.5
37	532–551	FRQIGIYSPNGQQYTPQDRE	2397.1569	2397.1582	−0.5
38	532–554	FRQIGIYSPNGQQYTPQDREQVA	2695.3195	2695.3223	−1.0
39	532–555	FRQIGIYSPNGQQYTPQDREQVAY	3698.0595	3698.0608	−0.4
40	555–571	YYKEDEKGQILQEGINE	2055.9862	2055.9869	−0.3
41	556–578	YKEDEKGQILQEGINELGAGCSW	2858.3880	2858.3856	0.8
42	579–585	LAAATSY	696.3562	696.3563	−0.1
43	586–598	STNNLPMIPFYIY	1572.7771	1572.7767	0.3
44	602–611	FGFQRIGDLC	1155.5615	1155.5615	0.0
45	612–621	WAAGDQQARG	1059.4964	1059.4966	−0.2
46	622–655	FLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNC	3589.7467	3589.7452	0.4
47	656–663	ISYDPAYA	899.4149	899.4145	0.4
48	664–667	YEVA	481.2296	481.2293	0.6
49	668–677	VIMHDGLERM	1200.5870	1200.5864	0.5
50	678–687	YGEKQENVYY	1292.5799	1292.5794	0.4
51	688–692	YITTL	610.3451	610.3447	0.7
52	693–708	NENYHMPAMPEGAEEG	1775.7008	1775.7000	0.5
53	709–745	IRKGIYKLETIEGSKGKVQLLGSGSILRHVREAAEIL	4062.3564	4062.3550	0.3
54	746–755	AKDYGVGSDV	1010.4791	1010.4789	0.2
55	756–761	YSVTSF	703.3302	703.3297	0.7
56	762–790	TELARDGQDCERWNMLHPLETPRVPYIAQ	3438.6706	3438.6682	0.7
57	791–802	VMNDAPAVASTD	1190.5362	1190.5358	0.3
58	807–819	FAEQVRTYVPADD	1510.7166	1510.7173	−0.5
59	820–844	YRVLGTDGFGRSDSRENLRHHFEVD	2962.4325	2962.4303	0.7
60	847–870	YVVVAALGELAKRGEIDKKVVADA	2514.4288	2514.4290	−0.1
61	848–886	VVVAALGELAKRGEIDKKVVADAIAKFNIDADKVNPRLA	4117.3491	4117.3496	−0.1
62	875–886	NIDADKVNPRLA	1325.7179	1325.7172	0.5