FIGURE 2.

Mogat1 ASO treatment improved glucose tolerance. A, Mogat1 inhibition led to decreased weight gain. B, reduced body weight after Mogat1 inhibition is associated with diminished weight of subcutaneous (SQ) and epididymal (EPI) white adipose tissue (WAT) depots. C, results of GTT studies in mice fed an LF or HTF-C diet and treated with control or Mogat1 ASOs. The bar graph at the right represents area under the curve values among the groups. n = 10 mice for all groups. *, p < 0.05 versus LF control and HTF-C Mogat1; **, p < 0.05 versus LF and HTF-C control. D, insulin-stimulated phosphorylation of Akt in hepatocytes isolated from mice treated with LF or HTF-C diet and control or Mogat1 ASO. Error bars, S.E.