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. 2014 Oct 10;5:5208. doi: 10.1038/ncomms6208

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Fitness (average±s.e.m., n=6), compared with the ancestral PAO1, of (a) nine plasmid-bearing clones (three per population) after one step of selection with neomycin from day 8 to 9, and (b) six plasmid-bearing clones (two per population) and (c) nine plasmid-free clones (three per population) from the same populations at day 30. Note that, as predicted by the model, immediately after antibiotic exposure (day 10) the population is composed both of PAO1/pNUK73 clones with the compensation and with a relative fitness similar to that of the parental. At the end of the experiment, however, all the plasmid-bearing clones have had a fitness cost compensatory mutation. Note that one of the plasmid-bearing clones at day 30 is marked with a star (30S+_2_2). This clone was excluded from the statistical analyses due to discrepancies between the fitness measurements in tubes and 96-well plates. The names of the clones are displayed in the x-axis and clones are arranged according to populations.