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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Int J Biochem Cell Biol. 2013 Jan 23;45(4):899–907. doi: 10.1016/j.biocel.2013.01.011

Fig. 3.

Fig. 3

Aβ increases generation of reactive oxygen species (ROS) in astrocytes, effect of antibodies and Ach. Addition of Aβ 1–40, 10 μM (A) Aβ 25–35, 50 μM (B) caused a clear increase in the rate of ROS generation (representing the traces from single cellos. The rate of increase of production was significantly reduced in the presence of antibodies to α7-type nAChRs or the NADPH oxidase inhibitor AEBSF (20 μM) ((C) and (D); signal is averaged), Ach and α-bungarotoxin also suppresses the effect of Aβ on the rate of ROS production (E). Histograms (C) and (D) show the fold increase in rate of HEt fluorescence as compared to the basal rate.