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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 7;22(17):5625–5629. doi: 10.1016/j.bmcl.2012.06.104

Figure 1. GSK2578215A inhibits LRRK2 in vitro.

Figure 1

(a) Chemical structure of GSK2578215A 1. (b) Enzyme activity of GSK2578215A. GST-LRRK2(1326–2517), GST-LRRK2[G2019S](1326–2517), GST-LRRK2[A2016T](1326–2517) and GST-LRRK2[G2019S + A2016T](1326–2517) were assayed using 20 μM Nictide in the presence of 100 μM ATP. Results are average of duplicate experiments.