Table 1.

Summary of selected glaucoma diagnostic accuracy studies

Study, year (reference)	Subjects	Number of eyes	Baseline MD (dB)	Device	Scan region	Parameter	AUC
Mwanza 20118	Glaucoma	73	−10.4	Cirrus SD-OCT	ONH RNFL	Vertical rim thickness Rim area RNFL average thickness	0.96 0.96 0.95
	Healthy	146	NA
Sung 20129	Glaucoma	229	−6.64	Cirrus SD-OCT	ONH RNFL	Rim area RNFL average thickness	0.87 0.96
	Preperimetric glaucoma	405	−0.66
	Healthy	109	−0.45
Kotowski 201210	Glaucoma	63	−2.21	Cirrus SD-OCT	Macular RNFL	GCC average GCIPL average RNFL average thickness	0.90 0.90 0.91
	Glaucoma suspect	49	−0.32
	Healthy	51	−0.18
Mwanza 201211	Glaucoma	58	−3.2	Cirrus SD-OCT	Macular ONH RNFL	GCIPL minimum GCIPL average Vertical cup to disc ratio Cup to disc ratio Rim area RNFL average thickness	0.96 0.94 0.96 0.93 0.91 0.94
	Healthy	99	0.08
Jeoung 201312	Glaucoma Mild Moderate/severe	164 142	−2.68 −12.41	Cirrus SD-OCT	Macular ONH RNFL	GCIPL minimum GCIPL average Rim area Cup to disc ratio RNFL average thickness	Mild, moderate/severe 0.90, 0.96 0.82, 0.91 0.86, 0.94 0.72, 0.86 0.90, 0.96
	Healthy	119	−0.22
Takayama 201213	Glaucoma Early Advanced	38 20	−2.33 −14.2	Cirrus SD-OCT	Macular RFNL	GCIPL minimum GCIPL average RNFL average thickness	All, early, advanced 0.94, 0.90, 0.99 0.87, 0.82, 0.96 0.92, 0.89, 0.96
	Healthy	48	−0.07
Lisboa 201314	Preperimetric glaucoma	48	−0.81	RTVue SD-OCT	Macular ONH RNFL	GCC average Vertical cup to disc ratio Rim area RNFL average thickness	0.79 0.74 0.72 0.89
	Healthy	94	0.02

AUC, area under receiver operating characteristics curve; GCC, ganglion cell complex; GCIPL, ganglion cell inner plexiform layer; MD, mean deviation; ONH, optic nerve head; RNFL, retinal nerve fibre layer; SD-OCT, spectral domain-optical coherence tomography.