Figure 1.

SCs perform a range of functions in the body. (a) During development, SCs sort axons based on their diameter and (b) deposit myelin on larger axons to increase conduction velocity of action potentials. (c) SCs aid axon regeneration by migrating into an injury site after a small injury, or into a transplanted nerve guidance channel (NGC) after a large injury. Once there, SCs proliferate and align. NGCs can also be pre-seeded with exogenous SCs to enhance regeneration. (Online version in colour.)