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Schematic of the proposed mechanism of RBCs migration and wall hypoxia. Shear-induced migration of RBCs takes places along the vessel wall inducing the initial RBC migration from the near-wall region. Secondary flows, induced by the vessel curvature, enhance RBC migration convecting them from the inner curvature side to the outer curvature one. This migration leads to a lowered haematocrit region on the inner curvature wall, which might results in localized hypoxia.
