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. 2014 Oct 24;8:81. doi: 10.3389/fnint.2014.00081

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Copyright © 2014 Gautam, Short and Verhagen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Across-glomerular pattern similarities. (A) The pattern similarity evoked by different concentrations (0.5, 1, and 1.5 log-units difference) of the same retronasal odor for response magnitude (dF/F) and dynamic parameters (start, t₁₀, t₅₀, t₉₀, t_peak and rise time) averaged across four rats. rand: pattern similarities based on identically processed random control data. Response magnitude patterns are well preserved across concentrations, but temporal patterns are not when the concentration difference is 10× or more (*one-sided paired t-test for mean > 0, P < 0.00065, n = 16–50 correlations based on 103 glomeruli of four rats boldfaced in Table 1A). (B) t₉₀ of glomeruli with slowest t90 versus fastest t90 quartile at 1% v.p. and their t₉₀ difference. These dynamics (296 ms difference) are only mildly preserved at 0.3% v.p. with a 96 ms difference (*one-sided paired t-test for mean difference > 0, P < 0.001, n = 16–17 mean t₉₀ values of 4–5 odors of same four rats) and not at 3 or 10% v.p. (C) The response magnitude and dynamic pattern similarity evoked by same concentrations (0.3–10%) across different retronasal odors averaged across four rats. Dynamics for one retronasal odor are poor predictors of those for another retronasal odor (*one-sided paired t-test for mean > 0, P < 0.00065, n = 25–28 correlations of 4–5 odors of same 103 glomeruli of four rats as in A). (D) Pattern similarity for 0.5-log spaced concentrations (same as in A) compared to pattern similarities across orthonasally and retronasally presented odorants at 4% v.p. based on a new analysis of a previously published dataset (Gautam and Verhagen, 2012b; n = 9 rats; *one-sided paired t-test for mean > 0, P < 10^-4, n = 70 correlations from 150 glomeruli from 9 rats, 4–8 odors and air per rat; #one-sided unpaired t-test for 4% ortho-retro > 0.5 log, P < 0.02, n = 4 and nine rats, response; all others ns). Late dynamic patterns are fairly similar between the two odor routes, and more so than across retronasal odors that differ by 0.5 log % v.p. concentration.