Figure 4.
CBDRP asymmetry index and PSPRP expression in individual CBD and PSP patients. (A) Using logistic regression analysis, we found that a discriminant function using CBDRP asymmetry index and PSPRP expression resulted in the best differentiation between CBDNS and PSPNS (χ2 = 15.6, P = 0.0004; likelihood ratio test) (see text). Scatter plot displays the CBDRP asymmetry index and PSPRP expression in the training sample of 10 patients with CBD and 10 age-matched patients with PSP. (B) The automated algorithm for differential diagnosis was prospectively validated on a case-by-case basis in a testing sample of 58 patients, including 17 patients with CBD and 41 patients with PSP (see text). Scatter plot displays the CBDRP asymmetry index and PSPRP expression for these patients. In both plots, CBD and PSP patients are indicated by blue and orange circles, respectively.