Table 1.
Median Concentrations and Interquartile Ranges of Seminal Plasma Cytokines
| Semen cytokine | Median concentration (pg/ml) | IQR | Median fluorescence intensity (FI) | Number out of rangea | Politch et al. valuesb |
|---|---|---|---|---|---|
| IL-1RA | 29.1 | 14.1–53.8 | 106 | 0 | Not done |
| IL-1α | 18.3 | 6.5–62.6 | 720 | 0 | 6.0 |
| IL-1β | 3.5 | 1.4–12.0 | 103 | 0 | 2.0 |
| IL-2 | 0.9 | 0.5–1.8 | 54 | 0 | <7.0 |
| IL-4 | 5.7 | 3.1–10.3 | 161 | 2 | Not done |
| IL-5 | 33.6 | 8.3–128.5 | 1,256 | 0 | 31.3 |
| IL-6 | 11.3 | 7.0–26.2 | 328 | 0 | 6.0 |
| IL-8 | 1,120 | 971–1,644 | 25,159 | 1 | 1,305 |
| IL-10 | 2.2 | 0.4–9.2 | 75 | 0 | <3.9 |
| IL-12 P70 | 1.7 | 0.7–2.5 | 59 | 2 | <5.0 |
| IL-17 | 0.9 | 0.0–1.8 | 203 | 7 | 11.6 |
| IFN-γ | 3.3 | 2.5–7.2 | 89 | 1 | <3.0 |
| MIP-1β | 37.8 | 15.5–138.2 | 690 | 0 | 66.0 |
| TNF-α | 1.6 | 0.9–4.5 | 137 | 0 | <2.0 |
| RANTES | 759 | 300–2,386 | 4,964 | 0 | 126 |
| TGF-β | 7,578 | 5,312–20,920 | 25,279 | 7 | 85,120 |
| TNF-RII | 1,075 | 374–4,710 | 5,616 | 0 | Not done |
a
Out of range specimens had FIs below the lowest values on the standard curves for all cytokines except TGF-β, where 6/18 semen specimens had FIs above the highest value on the standard curve and 1/18 had FIs below the lowest value on the standard curve.
b
Previously reported values in HIV-1-seronegative men from Politch et al.22
IL, interleukin; IFN, interferon; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor; TGF, tumor growth factor; IQR, interquartile range.