FIG. 2.

Statins attenuate Akt/mTOR signaling. (A) Representative western blots of Akt/mTOR signaling pathway proteins from HL-1 cells treated with vehicle (DMSO, solid bars) or simvastatin (statin, hashed bars) as indicated. (B) Quantitation of results shown in (A). n=3 per group; experiments were performed at least three times. *p-value<0.05. (C) Representative western blots of Akt/mTOR signaling pathway proteins in DMSO or statin-treated mouse hearts. n=4 mice per condition. (D) Quantitation of results shown in (C). Akt, protein kinase B; mTOR, mammalian target of rapamycin.