FIG. 3.

Mevalonate inhibits statin-induced attenuation of Akt/mTOR signaling and autophagy. (A) Representative western blots of Akt/mTOR signaling proteins and LC3 from HL-1 cells treated with statin in the absence (control) or presence of 100 μM mevalonic acid (mevalonate). Treatment groups identified as: vehicle (DMSO, solid bars) and simvastatin (statin, hashed bars). (B) Quantitation of results shown in (A). n=4 per group; experiments were performed at least three times with similar results. *p-value<0.05.