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. 2014 Oct 24;5:412. doi: 10.3389/fphys.2014.00412

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Copyright © 2014 Ranzinger, Rustom and Schwenger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of molecular mechanisms with implications for NT-mediated cellular interactions during PD. (A) The cartoon depicts the principle of NT-formation and NT-mediated transfer of organelles between cells. (B) The fluorescence microscopy picture shows NTs (arrows) spanned between primary human peritoneal mesothelial cells. (C) Illustration of the interdependence of NT-formation and communication in the context of PD-treatment including stimulating/inhibiting factors.