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. 2014 May 27;210(10):1605–1615. doi: 10.1093/infdis/jiu293

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 5. — Longevity of cellular immune responses after chemoprophylaxis and sporozoites (CPS) immunization. Plasmodium falciparum–specific cellular immune responses (corrected for uninfected red blood cell background) were assessed in protected (black dots) and unprotected (gray squares) CPS-immunized volunteers before CPS immunization (B), and before (C − 1) and 20 weeks after (C + 140) challenge infection. Data are shown as mean ± standard error of the mean for CD107a expression on CD4 T cells (A) and granzyme B production by CD8 T cells (B). Tests are performed separately for protected and immunized unprotected volunteers, by repeated-measures analysis of variance (including all time points before and after immunizations) and the Dunnett multiple comparison post test, using B as control column. Only the test results for C + 140, compared with those for baseline, for protected volunteers are displayed. For immunized unprotected volunteers, all results were nonsignificant. *P < .05 and **P < .01.