Table 1.

Protection Against Challenge Infection After Chemoprophylaxis and Sporozoites Immunization

Group	Protection		Day of Positivity After Challenge, Median (Range)c
	Proportiona	Percentage (95% CIb)	Thick Smear	qPCR
Group 1	4/5	80 (36.0–98.0)	12.0	9.5
Group 2	8/9	89 (54.3 to >99.9)	12.0	8.5
Group 3	5/10	50 (23.7–76.3)	11.0 (9.0–15.0)	9.0 (6.5–13.0)
Group 4	0/5	0 (0.0–48.9)	9.5 (9.0–13.5)	6.5 (6.5–10.5)

Subjects were exposed to bites from 15 infected mosquitoes on three occasions (group 1), to bites from 10 infected and 5 uninfected mosquitoes on three occasions (group 2), to bites from 5 infected and 10 uninfected mosquitoes on three occasions (group 3), or to bites from 15 uninfected mosquitoes on three occasions (group 4; control).

^a Data are no. of protected subjects/total no. of subjects.

^b 95% confidence intervals (CIs) were calculated by the modified Wald method.

^c Data are for thick-smear-positive subjects.