Figure 3.

Mitochondrial respiratory control and susceptibility to permeability transition (N = 5 for each group). (A) CsA treatment attenuated a heart failure‐induced decrease in mitochondrial complex I‐dependent respiratory coupling (black bars). (B–C) CsA reduced an increased susceptibility to Ca²⁺‐induced mitochondrial swelling, an index of MPT, observed in the HF group. Quantification of changes in absorbance in the presence of 25 μmol/L Ca²⁺ with or without CsA are presented in 3C as area above the curve of the traces in 3B. (*P < 0.05 vs. CON).