Figure 1.

The age‐dependent loss of α‐catenin. (A) Protein expression of α‐catenin was determined by western blot analysis of cortical lysates from male Fischer 344 rats at 4, 20, and 24 months; each lane represents a sample from an individual animal. (B) Densitometric analysis of α‐catenin expression, normalized to β‐actin, is shown; n = 3–7 animals, *indicates a significant difference from 4 months. (C) Age‐dependent loss of α‐catenin is also seen in the aging nonhuman primate kidney, as shown by western blot of kidney lysates.