Table 4.
mRNAs of structural plasticity
| Structural plasticity | Accession no. | Dyskinesia/nondys
|
dyskinesia/saline
|
Nondys/saline
|
P call %
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fold change | P value | Fold change | P value | Fold change | P value | Dyskinesia | Nondys | Saline | |||
| Upregulation | |||||||||||
| Homer | AB003726 | 1.25 | 0.012 | 1.09 | 0.343 | −1.15 | 0.147 | 100 | 100 | 100 | * |
| Homer | AF093267 | 1.18 | 0.015 | 1.3 | 0.041 | 1.1 | 0.413 | 100 | 100 | 100 | * |
| Homer (AB017140_at) | AB017140 | 1.16 | 0.024 | 1.19 | 0.140 | 1.03 | 0.817 | 100 | 100 | 100 | * |
| Homer (AB017140_g_at) | AB017140 | 1.15 | 0.035 | 1.21 | 0.054 | 1.05 | 0.564 | 100 | 100 | 100 | * |
| Densin-180 | U66707 | 1.24 | 0.023 | 1.34 | 0.017 | 1.08 | 0.521 | 100 | 100 | 100 | * |
| SAP-97 (discs, large homolog 1) | AI144926 | 1.26 | 0.011 | 1.28 | 0.033 | 1.01 | 0.914 | 100 | 83 | 66 | * |
| SAP-97 (discs, large homolog 1) | U14950 | 1.2 | 0.020 | 1.19 | 0.075 | −1.01 | 0.877 | 100 | 100 | 100 | * |
| SNAP-25 | AB003992 | 1.15 | 0.034 | 1.14 | 0.279 | −1.01 | 0.962 | 100 | 100 | 100 | * |
| Neurofilament, heavy polypeptide | AA818677 | 1.39 | 0.001 | 1.47 | 0.001 | 1.06 | 0.243 | 100 | 100 | 100 | * |
| Neurofilament, heavy polypeptide | X13804 | 1.08 | 0.108 | 1.11 | 0.036 | 1.03 | 0.359 | 100 | 100 | 83 | |
| Neurofilament, light polypeptide | M25638 | −1.05 | 0.472 | 1.29 | 0.020 | 1.35 | 0.006 | 100 | 100 | 100 | |
| Neurofilament, light polypeptide | AF031880 | −1.04 | 0.455 | 1.15 | 0.026 | 1.2 | 0.008 | 100 | 100 | 100 | |
| Gephyrin | X66366 | 1.12 | 0.002 | 1.12 | 0.024 | 1 | 0.995 | 100 | 100 | 100 | * |
| Integrin alpha-7 | X65036 | 1.26 | 0.002 | 1.28 | 0.001 | 1.02 | 0.647 | 100 | 33 | 16 | * |
| Syntaxin 1B | M95735 | 1.2 | 0.003 | 1.13 | 0.073 | −1.05 | 0.455 | 100 | 100 | 100 | * |
| Syntaxin 4 | L20821 | 1.26 | 0.005 | 1.09 | 0.278 | −1.16 | 0.112 | 100 | 100 | 100 | * |
| Syntaxin 6 | U56815 | 1.02 | 0.633 | 1.21 | 0.004 | 1.19 | 0.002 | 83 | 66 | 0 | |
| Neuron-specific protein PEP-19 (Purkinje cell protein 4) | M24852 | 1.17 | 0.004 | 1.08 | 0.107 | −1.09 | 0.088 | 100 | 100 | 100 | * |
| Adaptor protein complex AP-2, beta-1 subunit | AA964379 | 1.15 | 0.005 | 1.02 | 0.822 | −1.13 | 0.235 | 100 | 100 | 100 | * |
| Adaptor protein complex AP-2, alpha-2 subunit | X53773 | 1.21 | 0.042 | 1.35 | 0.008 | 1.12 | 0.167 | 100 | 100 | 83 | * |
| Reelin | AA893471 | 1.26 | 0.006 | 1.5 | 0.000 | 1.19 | 0.030 | 100 | 100 | 100 | * |
| f-Spondin | M88469 | 1.2 | 0.008 | 1.35 | 0.000 | 1.12 | 0.070 | 100 | 100 | 100 | * |
| p47 Protein (AB002086_at) | AB002086 | 1.12 | 0.012 | 1.16 | 0.008 | 1.03 | 0.419 | 100 | 100 | 100 | * |
| P47 Protein (AB002086_g_at) | AB002086 | 1.14 | 0.048 | 1.24 | 0.006 | 1.09 | 0.033 | 100 | 100 | 100 | * |
| Cadherin 22 | D83348 | 1.19 | 0.013 | 1.23 | 0.009 | 1.03 | 0.723 | 100 | 100 | 100 | * |
| Amphiphysin | Y13381 | 1.08 | 0.030 | 1.12 | 0.003 | 1.04 | 0.261 | 100 | 100 | 100 | * |
| Phosphatidylinositol-binding clathrin assembly protein | AF041373 | 1.1 | 0.031 | 1.12 | 0.035 | 1.01 | 0.840 | 100 | 100 | 83 | * |
| Component of rsec6/8 secretory complex p71 | U79417 | 1.16 | 0.037 | 1.3 | 0.006 | 1.12 | 0.135 | 100 | 100 | 100 | * |
| Arc; activity-regulated cytoskeletal- associated protein | U19866 | 1.23 | 0.043 | 1.04 | 0.641 | −1.18 | 0.016 | 100 | 100 | 100 | * |
| Actinin alpha-2 associated LIM protein | AF002281 | 1.13 | 0.046 | −1.01 | 0.921 | −1.14 | 0.055 | 100 | 100 | 83 | * |
| Synapsin 2 (rc_AI145494_g_at) | AI145494 | 1.16 | 0.069 | 1.64 | 0.000 | 1.41 | 0.006 | 100 | 100 | 100 | |
| Synapsin 2 (rc_AI145494_at) | AI145494 | 1.2 | 0.068 | 1.51 | 0.002 | 1.26 | 0.068 | 100 | 100 | 100 | |
| Synapsin 2 | M27925 | 1.06 | 0.423 | 1.33 | 0.001 | 1.25 | 0.023 | 100 | 100 | 100 | |
| Microtubule-associated protein 2 | X17682 | 1.24 | 0.073 | 1.56 | 0.003 | 1.25 | 0.188 | 100 | 100 | 100 | |
| Microtubule-associated protein 2 | X53455 | 1.19 | 0.059 | 1.35 | 0.008 | 1.13 | 0.284 | 100 | 100 | 83 | |
| Latexin | X76985 | 1.14 | 0.172 | 1.38 | 0.005 | 1.21 | 0.114 | 100 | 100 | 100 | |
| GERp95 | H31692 | 1.09 | 0.205 | 1.29 | 0.007 | 1.19 | 0.076 | 100 | 100 | 100 | |
| Narp; neuronal activity-regulated pentraxin | S82649 | 1.06 | 0.231 | 1.17 | 0.009 | 1.1 | 0.123 | 100 | 100 | 100 | |
| Dynamin 2 | AA851887 | 1.03 | 0.724 | 1.31 | 0.011 | 1.27 | 0.011 | 100 | 100 | 100 | |
| Neurexin 1 | AI146018 | 1.07 | 0.226 | 1.26 | 0.012 | 1.17 | 0.080 | 83 | 83 | 50 | |
| Integrin-associated protein (AF017437_at) | AF017437 | 1.02 | 0.787 | 1.26 | 0.015 | 1.23 | 0.006 | 100 | 100 | 100 | |
| Integrin-associated protein (AF017437_g_at) | AF017437 | 1.09 | 0.107 | 1.22 | 0.026 | 1.12 | 0.192 | 100 | 100 | 100 | |
| Downregulation | |||||||||||
| Neural cell adhesion molecule L1 | X59149 | −1.12 | 0.014 | −1.12 | 0.017 | 1.01 | 0.765 | 100 | 100 | 100 | * |
| Dynamin 2 | L25605 | −1.05 | 0.030 | −1.04 | 0.473 | 1.01 | 0.821 | 100 | 100 | 66 | * |
| Vesicle-associated calmodulin- binding protein | L22557 | −1.13 | 0.039 | −1.07 | 0.177 | 1.06 | 0.281 | 100 | 100 | 100 | * |
| Vascular cell adhesion molecule 1 | X63722 | −1.02 | 0.730 | −1.13 | 0.024 | −1.12 | 0.007 | 100 | 100 | 100 | |
Comparisons of gene expression changes between dyskinetic, nondyskinetic, and saline animals. Fold change and P values are presented. Upregulations are listed first, downregulations are underneath. In case of opposite regulations in different comparison groups, the comparison of dyskinetic to nondyskinetic animals decided placement. Percent present call (P call %) is given for each experimental group in the last three columns. The asterisk denotes significant differences between dyskinetic and nondyskinetic animals.