Table 5.

mRNAs of neurotransmitter synthesis, receptors, and transporters

Neurotransmitter synthesis, receptors and transporters		Accession no.	Dyskinesia/nondys		Dyskinesia/saline		nondys/saline		P call %
			Fold change	P value	Fold change	P value	Fold change	P value	Dyskinesia	Nondys	Saline
Upregulation
Cannabinoid receptor 1		X55812	1.35	0.000	1.25	0.029	−1.08	0.425	100	100	100	*
Somatostatin receptor 2		M93273	1.15	0.016	1.14	0.022	−1	0.929	100	100	100	*
Tachykinin 2 (neurokinin B, neuromedin K)		M16410	1.61	0.000	1.43	0.004	−1.13	0.316	100	100	100	*
Secretogranin II		M93669	1.37	0.003	1.34	0.005	−1.02	0.855	100	100	100	*
Cholecystokinin		X01032	1.41	0.054	2.26	0.000	1.61	0.063	100	100	66
Glutamate decarboxylase 1 (GAD67)	GABA	X57573	1.19	0.001	1.21	0.003	1.02	0.737	100	100	100	*
GABA-A receptor alpha-1		L08490	1.06	0.298	1.11	0.026	1.04	0.552	100	100	100
GABA-A receptor alpha-2		L08491	1.22	0.033	1.21	0.027	−1.01	0.935	100	100	100	*
GABA-A receptor alpha-4		S55933	1.31	0.073	1.83	0.002	1.4	0.057	100	100	100
GABA-A receptor alpha-4		L08493	1.08	0.129	1.1	0.025	1.02	0.605	100	100	100
GABA-A receptor beta-3		X15468	1.25	0.030	1.39	0.002	1.12	0.261	100	100	66	*
Vesicular GABA transporter		AF030253	1.12	0.035	1.18	0.008	1.05	0.298	100	100	100	*
Dopamine D1 receptor (S46131mRNA_r_at)		S46131	1.24	0.008	1.04	0.656	−1.2	0.053	100	100	100	*
Dopamine D1 receptor (S46131mRNA_s_at)		S46131	1.17	0.011	1.11	0.178	−1.05	0.441	100	100	100	*
Dopamine D1 receptor		M35077	1.16	0.023	1.08	0.445	−1.07	0.536	100	100	100	*
Glutamate/aspartate transporter 1 (glial)	Glutamate	S75687	1.15	0.041	1.03	0.726	−1.11	0.294	100	100	66	*
Glutamate/aspartate transporter 1 (glial)		X63744	1.21	0.039	1.52	0.001	1.26	0.049	100	100	100	*
Glutamate/aspartate transporter 3 (neuronal)		L35558	1.14	0.171	1.28	0.010	1.12	0.209	100	100	100
NMDA receptor NR1		S39221	1.1	0.123	1.31	0.002	1.2	0.018	100	100	100
NMDA receptor NMDA2C		U08259	−1.04	0.426	1.07	0.147	1.11	0.021	100	100	83
Glutamate receptor, metabotropic 3		M92076	1.11	0.074	1.16	0.022	1.05	0.404	100	100	100
Glutamate receptor, metabotropic 5		D10891	1.05	0.513	1.24	0.042	1.18	0.099	100	100	83
Downregulation
Neuropeptide Y		M15880	−1.12	0.030	−1.12	0.038	1	0.965	100	100	100	*
Tachykinin receptor 3 (tachykinin 2 receptor)		J05189	−1.06	0.042	−1.02	0.418	1.04	0.203	83	100	66	*
Cholinergic receptor, nicotinic, beta-4		U42976	−1.04	0.081	−1.07	0.016	−1.03	0.199	100	100	100
Dopamine D5 receptor	DA	M69118	−1.05	0.026	−1.04	0.096	1.01	0.646	100	100	83	*
Dopamine D3 receptor		A17753	−1.12	0.058	−1.15	0.021	−1.03	0.276	33	66	0
Dopamine transporter		M80570	−1.04	0.176	−1.07	0.040	−1.02	0.335	100	100	83
5-HT3 receptor		U01227	1.01	0.781	−1.06	0.044	−1.07	0.034	100	100	100
Glutamate receptor, ionotropic, kainate 2		Z11548	1.11	0.148	−1.12	0.218	−1.24	0.025	100	100	100

Comparisons of gene expression changes between dyskinetic, nondyskinetic, and saline animals. Fold change and P values are presented. Upregulations are listed first, downregulations are underneath. In case of opposite regulations in different comparison groups, the comparison of dyskinetic to nondyskinetic animals decided placement. Percent present call (P call %) is given for each experimental group in the last three columns. The asterisk denotes significant differences between dyskinetic and nondyskinetic animals.