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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Chem Res Toxicol. 2009 Mar 16;22(3):433–445. doi: 10.1021/tx8002752

Figure 4.

Figure 4

Ingenuity canonical pathway analysis. Differentially expressed genes were mapped to the Ingenuity Canonical Pathway library to identify significantly altered canonical signaling pathways. (a) ‘IL-10 Signaling’ and (b) ‘Role of BRCA1 in DNA Damage Response’ were influenced by 35 µM HNE at 24 h and 6 h, respectively. Genes or gene products are represented as nodes and the intensity of the node color indicates the degree of up- (red) or down- (green) regulation.