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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Pharm Res. 2010 Feb 17;27(4):619–627. doi: 10.1007/s11095-009-0037-6

Fig. 5.

Fig. 5

Apoptosis induction by procyanidins B2-G2 and B2-3’G is associated with caspase-9 and -3 and PARP cleavage and modulation in the levels of Bcl-2 family members. LNCaP cells were plated, left overnight and then treated with 0–50 µM of either B2-G2 or B2-3’G for 12 h. Total cell lysates were prepared and analyzed by western immunoblotting for cleaved caspase-9, -3, cleaved PARP, Bcl-xl, Bcl-2 and AR. Membranes were stripped and reprobed with β-actin as a loading control. Densitometric value shown below each band represents fold-change as compared to control after normalization with respective loading controls.