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. 2014 Oct 24;9(10):e109531. doi: 10.1371/journal.pone.0109531

Figure 4. Suppression of insulitis in SR-A−/− NOD mice.

Figure 4

The severity of islet inflammation was quantified by the degree of insulitis. Islets were categorized as follows: 0 (within normal limits, absent), 1 (the percentage of islet lymphocyte infiltration, 0–25%), 2 (25%–50%), 3 (50%–75%), and 4 (75%–100%). Five mice (15–20 weeks of age, average age 17.5 weeks) were analyzed and an insulitis score was calculated. The score was significantly suppressed in SR-A−/− NOD mice compared with littermates (* p value = 0.0262 by Mann–Whitney U test).