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. 2014 Oct 24;9(10):e110800. doi: 10.1371/journal.pone.0110800

Figure 5. CQGREEN uptake by resistant-type PfCRT is inhibited by mibefradil in a dose-dependent manner.

Figure 5

Microsomes were preincubated with varying concentrations of the PfCRT inhibitor mibefradil prior to addition of CQGREEN. At the highest concentration of 10 µM, mibefradil drastically suppressed CQGREEN uptake in PfCRT-Dd2 microsomes but had no significant effect on uptake in PfCRT-3D7 microsomes. *, ***: p<0.05 and p<0.001 respectively, against no mibefradil control (Ctrl). Data presented are means ± S.E.M.; n≥3.