Table 3. Cox Proportional Hazards Models for [TIMP-2]•[IGFBP7] (4 h) and clinical covariates.
| Clinical Model | Clinical Model with [TIMP-2]•[IGFBP7]3 | |||
| Variable1 | Hazard Ratio2 | p-value | Hazard Ratio2 | p-value |
| Gender | 1.414 (0.320–6.246) | 0.648 | 4.666 (0.647–33.627) | 0.126 |
| Age | 1.000 (0.998–1.003) | 0.683 | 0.998 (0.994–1.002) | 0.380 |
| Ventilation time | 0.997 (0.979–1.015) | 0.739 | 0.987 (0.946–1.030) | 0.557 |
| Bypass time | 1.007 (0.998–1.016) | 0.121 | 1.005 (0.996–1.014) | 0.320 |
| Prior surgery | 0.535 (0.139–2.057) | 0.363 | 0.467 (0.066–3.279) | 0.444 |
| BMI | 1.101 (0.835–1.451) | 0.496 | 1.307 (0.904–1.889) | 0.154 |
| RACHS-1 score | 0.722 (0.211–2.477) | 0.605 | 1.069 (0.257–4.446) | 0.927 |
| TIMP-2*IGFBP7 (4 h) | Not included in model | 2.872 (1.569–5.258) | 0.001 | |
1
reference category (underlined) for gender is male vs female, for RACHS score is 1+2 vs 3 and prior surgery no vs. yes. Age, ventilation time, BMI and [TIMP-2]•[IGFBP7] are included as continuous variables. Wald test. P values are reported.
2
95%-Confidence interval given in brackets;
3
Adding [TIMP-2]•[IFGBP7] improves the model significantly (p = 0.0002, likelihood ratio test).