Abstract
The effect of the antifungal drugs amphotericin B, fluocytosine, miconazole, griseofulvin, and nystatin on the chemotactic responsiveness of human neutrophils was studied. Amphotericin B in a concentration of 2 mug/ml inhibited chemotatic responsiveness, and in a concentration of 5 mug/ml it also inhibited chemiluminescence. The inhibition of chemotaxis could be reversed by washing the cells. The other antifungal drugs did not inhibit chemotaxis even in concentrations much higher than those obtained in human serum during treatment.
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Selected References
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- Allen R. C., Stjernholm R. L., Steele R. H. Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity. Biochem Biophys Res Commun. 1972 May 26;47(4):679–684. doi: 10.1016/0006-291x(72)90545-1. [DOI] [PubMed] [Google Scholar]
- De Nollin S., Borgers M. The ultrastructure of Candida albicans after in vitro treatment with miconazole. Sabouraudia. 1974 Nov;12(3):341–351. [PubMed] [Google Scholar]
- Forsgren A., Schmeling D., Quie P. G. Effect of tetracycline on the phagocytic function of human leukocytes. J Infect Dis. 1974 Oct;130(4):412–415. doi: 10.1093/infdis/130.4.412. [DOI] [PubMed] [Google Scholar]
- Hill H. R., Estensen R. D., Quie P. G., Hogan N. A., Goldberg N. D. Modulation of human neutrophil chemotactic responses by cyclic 3',5'-guanosine monophosphate and cyclic 3',5'-adenosine monophosphate. Metabolism. 1975 Mar;24(3):447–456. doi: 10.1016/0026-0495(75)90124-9. [DOI] [PubMed] [Google Scholar]
- Lehrer R. I. Inhibition by sulfonamides of the candidacidal activity of human neutrophils. J Clin Invest. 1971 Dec;50(12):2498–2505. doi: 10.1172/JCI106750. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martin R. R., Warr G. A., Couch R. B., Yeager H., Knight V. Effects of tetracycline on leukotaxis. J Infect Dis. 1974 Feb;129(2):110–116. doi: 10.1093/infdis/129.2.110. [DOI] [PubMed] [Google Scholar]
- Nelson R. D., Quie P. G., Simmons R. L. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975 Dec;115(6):1650–1656. [PubMed] [Google Scholar]
- Polak A. Effects of 5-fluorocytosine on protein synthesis and amino acid pool in Candida albicans. Sabouraudia. 1974 Nov;12(3):309–319. doi: 10.1080/00362177485380451. [DOI] [PubMed] [Google Scholar]