Table 3. Hazard ratios for myocardial infarction, stroke, or death according to baseline CHADS₂ and CHA₂DS₂-VASc scores.

Characteristic	Unadjusted, HR (95% CI)	P Value	Adjusted, HR (95% CI)§	P Value
Myocardial infarction or stroke
CHADS2≥2 vs <2	2.03 (1.46–2.81)	<0.001	1.87 (1.28–2.72)	0.001
CHADS2 score†	1.28 (1.13–1.44)	<0.001	1.25 (1.08–1.44)	0.002
CHA2DS2-VASc ≥2 vs <2	1.72 (1.19–2.48)	0.004	1.63 (1.10–2.47)	0.02
CHA2DS2-VASc score†	1.18 (1.08–1.29)	<0.001	1.18 (1.06–1.31)	0.002
Death
CHADS2≥2 vs <2	4.40 (3.12–6.06)	<0.001	3.17 (2.24–4.47)	<0.001
CHADS2 score†	1.74 (1.58–1.92)	<0.001	1.60 (1.41–1.80)	<0.001
CHA2DS2-VASc ≥2 vs <2	11.5 (6.42–20.8)	<0.001	8.52 (4.48–16.2)	<0.001
CHA2DS2-VASc score†	1.62 (1.50–1.75)	<0.001	1.55 (1.42–1.70)	<0.001
Myocardial infarction, stroke or death
CHADS2≥2 vs <2	2.74 (2.19–3.41)	<0.001	2.33 (1.81–2.99)	<0.001
CHADS2 score†	1.52 (1.40–1.65)	<0.001	1.44 (1.30–1.58)	<0.001
CHA2DS2-VASc ≥2 vs <2	3.42 (2.58–4.53)	<0.001	2.98 (2.17–4.07)	<0.001
CHA2DS2-VASc score†	1.41 (1.33–1.50)	<0.001	1.36 (1.26–1.46)	<0.001

HR = hazard ratio; other abbreviations as in Tables 1 and 2.

^§Adjusted for all clinical variables in Table 1 (except the 5 or 7 variables included in the CHADS₂ and CHA₂DS₂–VASc scoring systems, respectively), LVEF, Killip class, chronic kidney disease and medication at discharge.

^†Per unit increase in the original 6- or 8-criteria CHADS₂ and CHA₂DS₂-VASc scoring systems, respectively.