Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Autocrine stimulation of VHL negative ccRCC tumor cells by Activin B reduces RhoA activity thereby reorganizing the actin cytoskeleton and inducing invasiveness of spindle-shaped cells. Serum, which promotes RhoA activity, counteracts Activin B mediated effects. Rac1 activation by an unknown mechanism plays an opposite role to RhoA and is required for the invasive phenotype.
