Table 2.

Odds of overweight or obese among offspring of women using a pharmacologic sex hormone - by trimester of first use

				Overweight or obese (≥85th percentile)			Obese (≥95th percentile)
Exposure		Exposed n	Exposed cases n	Crude OR (95% CI)	Adjusted* OR (95% CI)	Exposed cases n	Crude OR (95% CI)	Adjusted* OR (95% CI)
Oral contraceptive**
	None	34,223	4,920	referent	referent	1,731	referent	referent
	Trimester 1	182	31	1.3 (0.9, 1.8)	1.4 (0.9, 2.0)	12	1.3 (0.8, 2.4)	1.7 (0.9, 3.0)
	Trimester 2	14	3	1.7 (0.5, 6.0)	1.8 (0.5, 7.0)	0	--†	--†
DES**
	None	34,288	4,929	referent	referent	1,730	referent	referent
	Trimester 1	86	15	1.2 (0.7, 2.1)	0.8 (0.5, 1.4)	8	2.0 (0.9, 4.0)	1.3 (0.6, 2.8)
	Trimester 2	39	9	1.6 (0.7, 3.4)	1.5 (0.7, 3.2)	4	2.0 (0.7, 6.0)	2.0 (0.6, 6.5)
	Trimester 3	6	1	1.2 (0.1, 10.1)	1.2 (0.1, 12.3)	1	3.7 (0.4, 31.9)	4.4 (0.3, 55.9)

^*adjusted for maternal smoking, education, parity, race, pre-pregnancy BMI, maternal age, and study center

^**trimester of first documented use in pregnancy -- trimester 1 corresponds to months 1–3, trimester 2 corresponds to months 4–6, and trimester 3 corresponds to months 7–9

^†not estimable