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. 2014 Oct 8;15(1):880. doi: 10.1186/1471-2164-15-880

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© Zuo et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Gene association network (GAN) 3 in lung. The network was generated with 791 BaP-significantly modulated genes by Ingenuity Pathway Analysis (IPA). (A) shows 28 BaP-modulated genes. The gene-gene interactions reveal that NFκb can be regulated by 10 genes (Ecsit, Gpam, Ddost, Cops3, Birc4, Otud7b, Nedd4, Ube2, Btrc and Rnf7) and it may regulate other 3 genes (Fuca1, Cyb5r3 and Ccnd2). It also shows that core genes NFκb and Ube give central roles for the network functions protein synthesis and post-translational modification. Up-regulated genes are shown in red; down-regulated genes are shown in green. (B) the descriptions of interactions and transcriptional factors.