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. 2014 Oct 9;14:103. doi: 10.1186/s12935-014-0103-y

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© Cheung et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CGH analysis of HCC21 cells and the original tumor. Vertical profiles of chromosomes 1, 2, 4, 8, 15, 16, 17 and 22 are shown with a log₂ ratio, which represents the difference between tumor and normal DNA copy number. Ratio of 0 indicates that there is no change in copy number between tumor and normal cell DNA. Positive and negative log₂ ratios indicate the gain and loss of tumor DNA copy number, respectively. The left panel of each plot represents the chromosome of the original clinical tumor specimen, while the right panel represents that of HCC21 cells at passage 10.