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. 2014 Oct 9;14:103. doi: 10.1186/s12935-014-0103-y

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© Cheung et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Tumorigenicity of HCC21 cells in immunocompromised mice. (A) Nude mice and NOD/SCID mice injected subcutaneously with 2x10⁶ and 1x10⁶ HCC21 cells, respectively, after 12 weeks. The middle panel shows the subcutaneous tumors derived from HCC21 cells 12 weeks after injection (scale bar = 10 mm). The lower panel shows the tumorgenicity of HCC21 cells. (B) Protein expression of HBV core antigen and AFP in patient’s tumor specimen, HCC21 xenograft tumors in NOD/SCID and nude mice, and cultured HCC21 cells at passage 12.