Table 1.
Variables, formulae, input values, and output results to calculate the ICER, the cost neutral price (Pn), and the maximum price of a new intervention (Pm) using a hypothetical model
| Variable | Formula | Input | Output |
|---|---|---|---|
| CostDNV | $60 | ||
| CostDv | CostDNV × (1 − VaccineEffect) | $6 | |
| CostV at Pn | CostDNV − CostDv | $54 | |
| E NV | 0.00031 | ||
| E V | E NV × (1 − VaccineEffect) | 0.000031 | |
| ICER (=y) at Pn | ((CostDv + CostV) − CostDNV)/(E NV − E V) | $0 | |
| VaccineEffect | 0.9 | ||
| a | 1/(E NV − E V) | 3,584.23 | |
| b | (CostDv − CostDNV)/(E NV − E V) | –193,548.39 | |
| y | a × Pn + b | $0 | |
| Threshold value | $40,000/E | ||
| Maximum price/course (Pm) | (40,000 − b)/(a) | $65.16 |
a slope of the linear regression, b intercept, CostD NV initial disease-related cost in the absence of vaccination (no vaccine), CostD v remaining disease-related cost with vaccination, CostV vaccine cost; E effect unit (life-year gained), E NV health losses without vaccination (no vaccine), E V remaining health losses (effects) with vaccination, ICER incremental cost-effectiveness ratio, Pm maximum price, Pn cost neutral price