Table 2.
Frequency of MBL deficiency-associated genotypes and MASP2 A/G heterozygosity
Group | C | NO | BT | OC G1-2 | OC G3 |
---|---|---|---|---|---|
n | 172 (174)a | 65 (67)a | 107 | 33 | 63 |
MBL deficiency-associated genotypes (LXA/O + O/O) (%) | 11.6 | 6.2 | 15 | 30.3b | 12.7 |
MASP2 A/G heterozygotes (%) | 8.6 | 7.5 | 9.3 | 24.2c | 7.9 |
LXA/O + O/O (MBL2) and A/G (MASP2) (%) | 0.6 | 0 | 0.9 | 12.1d | 0 |
C, control group, including NO, patients with no ovarian pathology and BT, patients with benign ovarian tumours; OC, patients with primary ovarian cancer
aNumbers of samples tested for D120G MASP2 polymorphism
b p = 0.05 (vs OC G3); p = 0.01 (vs C); p = 0.04 (vs NO); p = 0.07 (vs BT)
c p = 0.06 (vs OC G3); p = 0.02 (vs C); p = 0.03 (vs NO); p = 0.04 (vs BT)
d p = 0.01 (vs OC G3); p = 0.002 (vs C); p = 0.01 (vs NO); p = 0.01 (vs BT)