Fig. 4.

Correlation of ex vivo and post-IVS and ELISPOT and multimer responses in Phase I and II The responses of all donors (1–5), where appropriate, were assessed for the existence of significant (<0.01 %) correlation: Phase I, ex vivo ELISPOT with post-IVS ELISPOT (a); ex vivo multimer with post-IVS multimer (b); ex vivo ELISPOT with ex vivo multimer (c); Phase I and II, post-IVS ELISPOT with post-IVS multimer (d). Correlations were evaluated using the Pearson’s correlation coefficient (R) and the coefficient of determination (R ²), as shown on the bottom right of each graph. Significance testing used the Student’s t test and a confidence level of 99 %